For simple planes like in Rise of Flight, I think HOTAS plus Rift will be quite feasible for me - ditto most WW2 planes (though I can’t visualise how the bombsight view would work yet), but a modern jet still has me pretty stumped - especially say an FC3 plane without clickable cockpits. Voice attack or similar could be a goer for handling things like flaps, gear, cockpit opening, changing weapon stations and the like.
Chuck’s article has really increased my desire to try the Rift though - combat flying with it sounds amazing.