I don’t think so, mainly because it’s an upscaler, so it needs some sort of support to go from the low game resolution to the high resolution that’s upscaled. Things like Reshade run effects but I am not sure if they can do things like upscale. Using FSR with an OpenVR driver lets the device ask for and output different resolutions easily, but for 2D I’m not sure how that would work.
AMD open sourced the algorithm with the hope that developers would add it to games as an option. A few like GTA5 have injectors etc to make it work, but things like DOTA2 and Black Desert ship with it.
The Nvidia 496.76+ driver has a way to apply their very similar upscaler to any game without changes. They offer new resolutions to pick in-game (like a psuedo monitor resolution) and then it outputs it to native res using the scaler (plus with the performance benefit). Info on that here - Nvidia Image Scaler