As an addendum, as now we can all witness the firepower of this fully ARMED and OPERATIONAL battle station set of acronyms, here’s what I use day to day:
DCS VR - I use a NIS upscaler with the OpenVR FSR (bad name really, as it supports NIS too). Info here: OpenVR fholger VR Perf Kit (FSR) - #77 by fearlessfrog
MSFS VR - I use a NIS upscaler with the OpenXR API Layer too. Info here: Nvidia Image Scaler - #29 by fearlessfrog
I’m running a 3080 Ti, but those two above let me put the amp to 11 in VR. For 2D on the above, you can just use the Nvidia / AMD driver support to upscale with the virtual resolutions - they work well.
For stuff like Cyberpunk, Red Dead Redemption 2, No Man’s Sky etc, I use a 4K monitor so tend to peck around with the DLSS options for these. Gives a good framerate boost.