Yes - did a few goes with it. You can’t use the galaxy map router with it though. They have a slider so you can set your jump distance according to how much you’ve upped it by synthesis (25, 50 or 100%) but that just seems to confuse the route planner.
Talking of which - if you go exploring, don’t count too much on the accuracy of the galaxy map route planner. If you have a long route entered, when your session finishes it remembers the destination, but each time you start you have to go into the galaxy map and that will automatically make it set a new route - and it will very rarely be the same route as when you left it!
Example - yesterday I left my session with 47 jumps to my next destination. Today I started up and kicked off the planner and it came up with 55 jumps. I reset it and it then came up with 57 jumps!
I thought ‘what the hell’ and did a few jumps - sometimes that seems to give it a kick, and it comes up with what you were expecting, but this time it actually increased the jumps again. So just be aware that it has a mind of its own.
Also, there are some good planners on the internet:
https://www.spansh.co.uk/plotter/ - this for neutron jumping routes - note that it may be a longer route in LY, but it will be a lot less jumps - several hundred if you are going full range. (from Polo Harbour to the Bubble is over 700 jumps in the route planner - use this and it whittles down to 354 jumps - huge difference) but bear in mind you need to make small diversions for fuel now and then.
https://www.edsm.net/en/map/planner is another I use now and then.
Be aware that if you go off the beaten track, these planners are useless. They only cover the well trodden routes and systems.